Methotrexate Overview

    1. Methotrexate is never given daily for seven (7) consecutive days. Once a week is the most commonly prescribed dose, (at the same time, on the same day each week). Sometimes, a physician may prescribe divided doses (i.e. 2 to 3 times per week) depending upon the client’s condition and response. 
    2. Methotrexate oral tablets are not to be crushed or cut prior to administration;
    3. Whether methotrexate is administered in a home or community-based setting, PPE precautions apply. These includes: 1) good-quality, powder-free gloves, 7-9 mm thick made of latex, nitrile, polyurethane or neoprene; 2) disposable, moisture-resistant, long sleeved gowns with knit cuffs; 3) Eye Protection / Chemical Splash Goggles as well as eye wash facilities (e.g., sink with eye wash station or an eye wash bottle) and 4) disposal facemasks (i.e. N95 version) for protection. Note: In the Stoney Health center, the eyewash sink is located in the Treatment Room
    4. Methotrexate in intact pre-filled syringes is not to be removed from the syringe or primed prior to administration;