Use cautiously in people with :
- who are breastfeeding (NB: B12 may pass into breast milk
- with low serum levels of potassium (NB: the correction of megaloblastic anemia with vitamin B12 may result in fatally low potassium levels);
- with a history of cancer and skin disorders (NB: rash, itching, and burning have been reported
- with gastrointestinal concerns (NB: nausea, difficulty swallowing, and diarrhea have been reported.
- with high blood pressure and blood disorders (NB: it has been reported that treatment of vitamin B12 deficiency may lead to an increase in blood volume and the number of red blood cells);
- with a history of gout, or elevated uric acid levels (NB: the correction of megaloblastic anemia with vitamin B12 may start a gout attack)